PD Medication Options for Off Episodes
In Parkinson's disease, "off" episodes refer to times when medication (such as levodopa) wears off or loses effectiveness. During these periods, Parkinson’s symptoms—like tremors, stiffness, slowness, and anxiety—return or worsen until the next dose kicks in.
Understanding the types, signs, and available management strategies can help minimize these disruptive fluctuations.
Types of "Off" Episodes
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Wearing Off: The most common type, where the medication effect fades before it is time for the next scheduled dose.
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Delayed ON: When it takes longer than usual for a dose to start working after it is taken.
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Unpredictable OFF: When symptoms return suddenly and unexpectedly, even if the medication schedule is followed perfectly.
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Dose Failure (Partial ON): When a dose is taken, but the medication provides little to no relief of symptoms.
APOKYN is used by injection, as needed, to treat loss of control of body movements in people with advanced Parkinson's disease (PD). This condition is also called hypomobility or off episodes. An off episode may include symptoms such as muscle stiffness, slow movements, and difficulty starting movements.